Targeted Radionuclide Therapy: Practical Applications and Future Prospects
نویسندگان
چکیده
منابع مشابه
Targeted Radionuclide Therapy: Practical Applications and Future Prospects.
In recent years, there has been a proliferation in the development of targeted radionuclide cancer therapy. It is now possible to use baseline clinical and imaging assessments to determine the most effective therapy and to tailor this therapy during the course of treatment based on radiation dosimetry and tumor response. Although this personalized approach to medicine has the advantage of maxim...
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Targeted radionuclide therapy is based on systemic application of particle-emitting radiopharmaceuticals which are directed toward a specific tumor-associated target. Accumulation of the radiopharmaceutical in targeted cancer cells results in high doses of absorbed radiation energy whereas toxicity to non-targeted healthy tissue is limited. This strategy has found widespread application in the ...
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Purpose: Adequate dosimetry is mandatory for effective and safe peptide receptorradionuclide therapy. The radiation-dose to the bone marrow can be calculated from theresidence time of the radiopeptide in the blood, but it might be underestimated since stemcells express somatostatin-receptors. We verified the blood-method by comparing the resultswith bone marrow aspirations. Also...
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Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the...
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ژورنال
عنوان ژورنال: Biomarkers in Cancer
سال: 2016
ISSN: 1179-299X,1179-299X
DOI: 10.4137/bic.s31804